EGF and neoplasm: Mucin-1 plays important roles in cancer development and metastasis by inhibiting the anti-tumor immune response [29], promoting the growth of cancer cells by binding to EGFR in an epidermal growth factor-dependent manner [30], preventing cell death by inhibition of p53-mediated apoptosis and promotion of p53-mediated cell cycle arrest [31], and promoting cancer metastasis [32-34].