In their study, levels of nine proteins including tubulin β-2, phosphoglucomutase-3 (PGM3), melanoma-derived leucine zipper containing extra-nuclear factor, activin A type I receptor precursor, smoothelin-A, KIA0073, hypothetical protein LOC57691 and two unnamed proteins changed over 8 folds in SFN treated LNCaP cells compared to untreated control by using MALDI-TOF [21]. This evidence concerns the gene ACVR1 and melanoma.