In this sense, it is conceivable that up-regulation of GRP94 allows the correct folding of several oncogenic products promoting the colorectal carcinogenesis, although this increase has also been related with the acquisition of survival mechanisms by tumour cells to stand up lethal conditions, such as glucose starvation and hypoxia, and with the ability to form new distant solid tumours [30]. Here, HSP90B1 is linked to neoplasm.