Although various inflammatory cytokines are reported to influence vascular permeability in the eye and to be related to macular edema in patients with CRVO, there is little evidence regarding the relationship of SRD to inflammatory molecules such as soluble VEGFR-2 (sVEGFR-2), soluble ICAM-1 (sICAM-1), and PEDF. Here, SERPINF1 is linked to macular retinal edema.