CXCR7 has been implicated in enhancing cancer cell adhesion to fibronectin and endothelial cells [2,23,27]; increasing cell survival by decreasing apoptosis [2,23] and promoting primary tumor growth of lymphoma, lung, breast, prostate and hepatocellular cancer cells [2,22,23,27]. The gene discussed is ACKR3; the disease is hepatocellular carcinoma.