However, in line with previous reports [23,27], we observed increased blood vessel density in MTLn3 CXCR7 and MTLn3 CXCR4-CXCR7 primary tumor sections compared with control MTLn3 JP (P < 0.005) and MTLn3 CXCR4 tumors (P < 0.05), respectively (Figure 4b) using a CD34 antibody, suggesting that CXCR7 overexpression increases the growth of the primary tumor by stimulating angiogenesis. Here, ACKR3 is linked to neoplasm.