Because SNAI2 has been implicated in EMT and in the invasive metastatic behavior of breast and other cancer cells [3,4] we employed the MCF7/Rx2dox culture system to test the hypotheses that Runx2 induces and E2 antagonizes EMT and invasiveness, and that SNAI2 plays a role in these processes. The gene discussed is SNAI2; the disease is cancer.