Finally, in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, ELISA detected IgG antibodies against the HHV-8 K8.1 structural protein in study entry serum samples from 103 (13.5%) of 765 and 103 (11.3%) of 915 white prostate cancer cases and age-matched controls, respectively (OR 1.3, 95% CI 0.9-1.7) and in 2 (1.9%) of 103 and 22 (6.0%) of 367 black cases and age-matched controls, respectively (OR 0.3, 95% CI 0.1-1.4; [11]). This evidence concerns the gene PROS1 and cancer.