Including men with non-elevated (< 4.0 ng/mL) Wave 1 PSA and men with elevated (≥ 4.0 ng/mL) Wave 1 PSA, but prostate cancer not seen on Wave 1 biopsy, case-cohort analysis did not observe HHV-8-related incident prostate cancer risk in men overall (age-adjusted HR 0.88, 95% CI 0.46-1.69), in men with Wave 1 PSA < 4 ng/mL (age-adjusted HR 1.03, 95% CI 0.49-2.16), or in men without a positive Wave 1 prostate cancer screen result (age-adjusted HR 1.02, 95% CI 0.44-2.39; Table 4). The gene discussed is PROS1; the disease is Familial prostate cancer.