As described in HAM/TSP patients[34], Tax-specific CD8+ T-cells in both ACs (#287 and #313) were primarily enriched in TEM memory pool in spite of the functionality of Tax-specific CD8+ T-cells (Figure 5A), which may support continuous or periodical expression of viral antigen in vivo during an asymptomatic stage. Here, CNTN2 is linked to tropical spastic paraparesis.