We found that a combination of sPLA2-IIa (2.4 ng/ml cutoff value), Cyfra 21.1 (3.3 ng/ml cutoff value), and CEA (6 ng/ml cutoff value) tests increased the sensitivity for lung cancer prediction up to 62% from 48% by sPLA2-IIa test alone for 96 cancers relative to 29 patients with benign SPNs from the BNLCC (Table 3b and see Additional file 1 and 4). This evidence concerns the gene CEACAM5 and lung cancer.