SFTPC and lung carcinoma: We also found that sPLA2-IIa was overexpressed in lung cancer tissue, but not the adjacent normal type I and II epithelial cells in the spontaneous mouse lung cancer from SP-C/TAg transgenic mice, in which the transgene SV40 early region (TAg) gene was driven by a 3.7 kb promoter of human surfactant protein C (SP-C) gene (Figure 3i) [28,29].