FLCN and colonic neoplasm: Nahorski et al (2010) found evidence that the risk may be dependent on the FLCN genotype. Recently, in family BHD15, one of the FLCN mutation carriers developed symptomatic colonic cancer at age 62 years. Late-onset colorectal cancer has been diagnosed in several other FLCN mutation carriers from our BHD cohort not included in the present study.