This is in line with earlier results from experimental approaches using genetically engineered mice to elicit wt p53 expression in oncogene-driven lymphomas and sarcomas (Martins et al, 2006; Ventura et al, 2007), and in liver tumours with inducible p53 expression in the tumour cells (Xue et al, 2007). Here, TP53 is linked to sarcoma.