The pancreatic cancer cell lines DanG and MiaPaCa-2 harbour mutated TP53 alleles (Moore et al, 2001), resulting in the accumulation of a stabilised mutant protein (Midgley and Lane, 1997), which is easily detected by western blot analysis with a TP53 antibody (Figure 1A in the lane without Dox). This evidence concerns the gene TP53 and familial pancreatic carcinoma.