TP53 and neoplasm: Restoration of the wt TP53 function has been achieved in different tumour cell systems, including pancreatic cancer cells (Lang et al, 1998; Cascallo et al, 1999; Ghaneh et al, 2001), and resulted in cell cycle arrest or apoptosis, and insensitivity to radiation (Liu et al, 2009) or chemotherapy (Sullivan et al, 2004).