Although wt TP53 has previously been reintroduced in permanent pancreatic cancer cell lines (Lang et al, 1998; Ghaneh et al, 2001), little is known about the consequences of wt TP53 reexpression for more complex, context-driven aspects of pancreatic cancer growth, upon which we focused in the current study. Here, TP53 is linked to familial pancreatic carcinoma.