LYVE1 and neoplasm: Strikingly, all tumours with wt TP53 reconstitution contained more LYVE-1-positive lymphatic vessels than control tumours, increasing the LVD by 203% at 4 weeks (28 vs 9, P=0.0011) and by 39% at 8 weeks (32 vs 23, P=0.0214) (Figure 3D).