Urine peptidome pathway analysis revealed that the intrinsic prothrombin activation pathway (P = 3.04 × 10-5), hepatic fibrosis/hepatic stellate cell activation (P = 6.49 × 10-4), dendritic cell maturation (P = 0.001), and IL-6 signaling (P = 0.01) were significantly down-regulated in KD compared to FC. The gene discussed is IL6; the disease is Hepatic fibrosis.