ATP7B and Alzheimer disease: Recently, it has been demonstrated that metal dyshomeostases linked to mutations and polymorphisms of specific genes, such as ATP7B in Alzheimer's disease (AD, [7]), the gene of ceruloplasmin in Parkinsons' disease (PD, [8, 9]), the gene of hemochromatosis (HFE) in multiple sclerosis [10, 11] and in AD [12–14], increase the risk of developing those diseases.