Mono- or biallelic deletions, missense, nonsense, and frameshift mutations in RUNX1 are also found in patients with de novo AML, MDS, chronic myelomonocytic leukemia, and in therapy-related MDS and AML [1], [2], [3], [4], [5], [6], [7]. Here, RUNX1 is linked to acute myeloid leukemia.