Multiple pituitary hormone deficiency (MPHD) results from a variety of transcription factor mutations, including mutations in PROP1, POU1F1 (PIT1), HESX1, LHX3, LHX4, OTX2, SOX2, SOX3, and GLI2 (reviewed in [3]). This evidence concerns the gene POU1F1 and hypopituitarism.