Interestingly, NO level is higher in obese subjects [179] and rats [180], and the transcription factor complex hCHOP-C/EBPα, known to cause NO-dependent downregulation of SLC29A1 expression in HUVEC from GDM pregnancies (see above) [51], is also expressed in human adipocytes and involved in the downregulation of expression of other membrane transporters, such as SCL2A4 (for GLUT4) [181]. Here, SLC29A1 is linked to gestational diabetes.