However, most mice with PrPC-expressing FDC in their spleens succumbed to clinical prion disease after i.p. injection (Prnp+/-→ Prnp+/- control mice, n = 5/7; CD21-Cre Prnpflox/-→Prnpflox/- mice, n = 3/6; Table S1). Here, CR2 is linked to prion disease.