We found that changes in kidney histopathology and plasma BUN levels showed no significant difference between the p53+/+ and p53–/– mice at eight and 12 weeks following 5/6 Nx, which indicates that both p53+/+ and p53–/– mice developed to the same stage of CKD at the same time following 5/6 Nx. This evidence concerns the gene TP53 and chronic kidney disease.