Joseph, MI) regulatory network analysis [50] indicated that both NOV and ENPP2 are indirectly regulated by the 8q24 proto-oncogene c-MYC (Figure 2), via p53 (for NOV) [51,52] and ESR2 (for ENPP2) [53,54], indicating their potential involvement in a pathway for cancer susceptibility. The gene discussed is ESR2; the disease is cancer.