BRAF and malignant colon neoplasm: In particular, rs6993464 has been shown to be an eQTL for POLR2F, a gene on chromosome 22 which is up-regulated in colorectal cancer [56], while rs7000665 regulates expression of BRAF, a gene which plays an important role in tumorigenesis in thyroid cancer [57] and melanoma [58], as well as in survival in colon cancer [59].