Indeed, we showed that ERK1/2 is involved upstream of PKCα and β to regulate AXL expression in TKI-resistant CML cells since inhibition of MEK1 by U0126 abrogated PKCα and β translocation and as consequence on AXL expression only in IM-resistant cells. This evidence concerns the gene MAP2K1 and chronic myelogenous leukemia, BCR-ABL1 positive.