CD8A and breast cancer: In order to determine whether irradiation-induced up-regulation of CT-antigens and MHC-I results in increased recognition by antigen-specific CD8+ T cells, we measured degranulation [23]–[24] of NY-ESO-1157-165/HLA-A2-specific cloned CD8+ T cells upon incubation with irradiated and non-irradiated HLA-A2+ MDA-MB-469 breast cancer cells.