To identify specific genes involved in Type I IFN signaling modulated by HIV-1 infection, gene expression in IFNα2 pre-treated macrophages infected or not with HIV-1 was measured at 2, 4, 8, and 24 hours post-infection using high-density oligonucleotide microarrays (U133 Plus 2.0 arrays). This evidence concerns the gene IFNA2 and HIV-1 infection.