DHTKD1 and infection: We first determined the kinetics of HAdV-5 replication in HBECs, which is as follows: E1A expression starts before 4 hours post-infection (h.p.i.)and reaches a plateau at 8 h.p.i.; the first increase in viral genome and fiber mRNA copies occurs at 8 or 12 h.p.i., dependent on the donor, and infectious particle production reaches a plateau at 48 h.p.i..