PNPLA3 and steatosis: Adiponutrin is expressed in the liver and adipose tissue, has both triacylglycerol hydrolase and acylglycerol transacetylase activity [11] and it was suggested that the 148M allele encodes for a loss-of-function variant that predisposes to steatosis by decreasing triglyceride hydrolysis in hepatocytes [12].