Furthermore, in two series of biopsied patients the presence of the 148M allele influences both the presence of NASH and the severity of fibrosis in patients with NAFLD, irrespectively of the degree of obesity, the presence of diabetes, and the previously demonstrated effect of adiponutrin genotype on steatosis [13], [14]. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatohepatitis.