In order to demonstrate the pivotal role of IL-1 signaling on cardiac remodeling after AMI, we studied two independent strains of mice with genetic modifications that alternatively enhanced IL-1 signaling (IL-1Ra deletion, IL-1Ra-/-) or suppressed IL-1 signaling (IL-1R1-/-) in a model of severe ischemic cardiomyopathy due to permanent coronary artery ligation. This evidence concerns the gene IL1A and ischemic cardiomyopathy.