However, we observed that the reduced expression level of NESG1 was markedly correlated with lymph node metastasis (N classification) (N0–N1 vs. N2–N3) (P = 0.005), distant metastasis (N classification)(P = 0.024), and clinical stage (I–II vs. III–IV) (P = 0.003) in NPC patients. The gene discussed is CFAP45; the disease is nasopharyngeal carcinoma.