PSMB6 and Autoimmunity: As presented here, treatment with Y-MSPc was consistently more effective than treatment with relevant peptide cocktail, both in suppressing the development of “complex EAE” and in ameliorating ongoing disease, via the induction of more efficacious and longer lasting peripheral regulatory mechanisms; and, of most significance for its potential clinical utility, the Y-MSPc was also more effective in the reversal of ongoing “complex EAE” associated with multiple pathogenic anti-myelin autoimmunity.