We have now generated a more comprehensive and human-specific (HLA-DR2 relevant) multi-targeting agent, designated Y-MSPc (Y-MS related Protein), the product of a synthetic gene encoding a wide spectrum of rationally selected MS-relevant epitopes of all the five known major encephalitogenic target antigens in MS; MBP, PLP, MOG, MOBP, and OSP. Here, MBP is linked to myeloid sarcoma.