NLRP1 and myeloid sarcoma: However, assuming that after decades of intensive investigation by numerous laboratories worldwide, most of the major encephalitogenic target antigens in MS have been defined, it is likely that ‘cumulative’ specific regulatory mechanisms induced by the different major MS-relevant epitopes encompassed by the Y-MSPc-like multi-epitope protein may downregulate, via ‘cumulative bystander suppression’, also autoimmune T-cells reactive against other potential target (minor) antigens not represented within the “multi-epitope targeting” protein.