Elevated levels of ATX have been demonstrated to play a role in migration and invasion of glioblastoma, lymphoma, hepatocellular carcinoma, melanoma and breast cancers, establishing this enzyme as a likely mediator of metastatic disease [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46]. Here, ENPP2 is linked to breast carcinoma.