MCF-7 and BT474 breast cancer derived cell lines expressed low levels of pStat3 and no to low expression of ATX mRNA; while 1937, 1806, 1143, 38, MDA-MB-231, 1833, 4175 and MDA-MB-435 cells expressed high levels of pStat3 protein and ATX mRNA (Fig. S1A and Fig. 5A). This evidence concerns the gene ENPP2 and breast carcinoma.