TNF-α −308 G/A SNP, a functional polymorphism, has shown association with severe forms of malaria [14], leishmaniasis [15], and leprosy [16], in conjunction with raised levels of TNF-α in peripheral blood, but this SNP has shown no association with either disease susceptibility [17]–[18], [19], or severity in TB [20]. This evidence concerns the gene TNF and malaria.