In the present study, we tested two related hypothesis regarding a potential role of Cstb in the pathogenesis of epilepsy: (1) Overexpression of Cstb, like underexpression, could induce EPM1-like phenotypes; and (2) Cstb could be a candidate gene for increased susceptibility to epilepsy in DS. The gene discussed is CSTB; the disease is Dravet syndrome.