SOD1 and temporal lobe epilepsy: Finally, SOD1, a major cytoplasmic antioxidant enzyme converting superoxide radicals to molecular oxygen and hydrogen peroxide and whose gene is present on Hsa21 and Mmu17, was recently identified as a possible epileptic biomarker in a proteomic analysis of cerebrospinal fluid (CSF) from patients with temporal lobe epilepsy (TLE) [91].