There are seven approved treatments for adults with chronic hepatitis B (CHB) in the United States and European countries: interferon (IFN) α, pegylated (PEG) IFN-α, lamivudine (LAM), adefovir dipivoxil (ADV), entecavir (ETV), telbivudine (TBV), and tenofovir disoproxil fumarate (TDF). Here, IFNA1 is linked to chronic hepatitis B virus infection.