However, depletion of the core subunits INI-1 or BRG1 or the BAF-specific subunit BAF250 resulted in a significant, greater than 50% lower incidence of latent infections in both Jurkat and SupT1 cells, while depletion of PBAF-specific subunits had no significant effect on latency establishment (Fig 8D and S7C Fig). The gene discussed is SMARCB1; the disease is disease arising from reactivation of latent virus.