CHDH and coronary artery disorder: While the modules in central place of the CHD subnetwork are enriched in core CHD-related dysfunctional processes, such as anatomical structure morphogenesis, cell differentiation and cytoskeleton organization, and regulate key pathways of CHD such as cardiac muscle contraction, Notch signaling pathway and ECM (extracellular matrix)-receptor interaction, the modules in peripheral place are enriched in auxiliary processes, such as cell communication and various metabolic processes, and regulate less disease-related pathways.