When lung fibroblasts were treated with rosiglitazone in a concentration of 20 μM for 24 hours, MMP-1 activity was increased in lung fibroblasts from white SSc-ILD patients; such treatment, however, had no effect on MMP-1 activity in SSc-ILD fibroblasts from black patients (Figure 2(a)). Here, MMP1 is linked to systemic sclerosis.