BAX and cancer: In our study, we have demonstrated that the incubation of several lines of human cancer cells, of different histology, with 20 μM simvastatin caused a significant increase in Bax expression and a decrease in BCL-2, both at mRNA and protein levels, and as a consequence of this gene expression deregulation, we observed strong apoptosis induction, after addition of simvastatin, in all the cancer cell lines examined.