Currently, it is generally accepted that one of the major factors contributing to the resistance of pancreatic cancer cells to treatment with chemotherapeutic agents is represented by the autocrine epidermal growth factor (EGF)-mediated signaling which results in stimulation of the PI3K pathway and is required for transformation of several cell lineages by RAS-family oncogenes (8,9). Here, EGF is linked to familial pancreatic carcinoma.