4: Calculation of receiver operating characteristic (ROC) curves for the models predicting HCH based on the linear combination of age, hemoglobin, albumin, creatinine, ALT, and eGFR demonstrated significance at p < 0.005 when compared to ROC area calculations for models based on the non- weighted Z scores for those same variables or CKD stage alone. This evidence concerns the gene ALB and hypochondroplasia.