To determine the role of AEG-1 in the clinical progression of SGC, IHC analysis was performed in 141 paraffin-embedded, archived SGC tissue samples, including nine histological types of SGC: mucoepidermoid carcinoma, adenoid cystic carcinoma, acinar cell carcinoma, adenocarcinoma, squamous cell carcinoma, salivary duct carcinoma and basal cell carcinoma. The gene discussed is MTDH; the disease is mucoepidermoid carcinoma.