Ninety-two percent of patients received systemic chemotherapy with curative intent (29% and 71% in the neoadjuvant and adjuvant settings, respectively) for their primary BC (Table 1), whereas 55% (HR+/HER2-) received endocrine therapy, and 17% (HER2+) received trastuzumab. The gene discussed is ERBB2; the disease is breast cancer.