EGFR FISH positivity was not associated with clinical-pathological features, including age (P = 0.265), lymph node metastasis (P = 0.765), disease stage (P = 0.748), tumor type (P = 0.551), ER status (P = 0.464), PR status (P = 0.943), and HER2 status (P = 0.733). Here, ESR1 is linked to metastasis.