EGFR and head and neck squamous cell carcinoma: Due to the availability and benefit of anti-EGFR therapies, including both monoclonal antibodies (MoAbs) and small molecule tyrosine kinase inhibitors (TKI), for the treatment of various solid malignant tumors, such as non-small cell lung cancer (NSCLC), squamous cell carcinoma of the head and neck (HNSCC), and colorectal cancer (CRC), the role of EGFR gene status has been investigated in a number of clinical studies.