INS and Insulin resistance: Because elevated blood insulin increases hepatic lipogenic gene expression via transcription factors such as SREBP-1c [16, 86, 87] and glucokinase is an important mediator in this lipogenic pathway [16, 88], ezetimibe treatment may protect against diet-induced hepatic steatosis by reducing hepatic lipogenesis, mostly through preventing diet-induced insulin resistance and the associated hyperinsulinemia.