The neural histogenetic origin of GCT was also proposed after immunohistochemical analysis of 15 oral lesion by Rejas et al. who found a positive staining for S-100, P75, NSE, and CD68 while other markers including Ki-67, Synaptophysin, HHF-35, SMA, EMA, Chromogranin, Progesterone, Androgen, and Estrogen were negative [29]. The gene discussed is SYP; the disease is granular cell tumor.