RPS6KB1 and neoplasm: Karni and collaborators showed that SRSF1 affects the alternative splicing of the tumor suppressor BIN1, producing an isoform lacking tumor suppressor activity, and of the protein kinases MNK2 and S6K1, leading to an MNK2 isoform promoting MAPK-independent eIF4E phosphorylation and an S6K1 isoform with oncogenic properties [66].