AKT1 and proliferative diabetic retinopathy: An indication suggesting that the inhibition of PI3K/Akt/mTOR pathway could have beneficial therapeutic effects for the management of proliferative diabetic retinopathy stems from the findings that growth factors known to play major roles in the induction of angiogenesis depend on PI3K/Akt/mTOR for prolonging the cell survival signals that are operant in pathological angiogenesis [46].