We and others have shown that the C allele of the single nucleotide polymorphism (SNP) rs5743836 (T-1237C) in TLR9, known to display minor allele frequencies ranging from 0.02 to 0.38 across distinct ethnicities, predisposes to non-Hodgkin [12] and Hodgkin lymphoma [13], as well as to several autoimmune and chronic inflammatory diseases, including asthma [14] and Crohn's disease [15]. Here, TLR9 is linked to asthma.