CD4 and tuberculosis: Advanced clinical stage (aRR 1.12, 95%CI 1.03–1.23 for stage 4; compared to stage 1 or 2), presence of tuberculosis at ART start (aRR 1.15, 95%CI 1.04–1.26), and low initial CD4 cell counts (aRR 0.93, 95%CI 0.83–1.03 for 50–99; aRR 0.86, 95%CI 0.78–0.94 for 100–199; and aRR 0.89, 95%CI 0.80–0.99 for ≥200; compared to <50 cells/μl) were also associated with increased toxicity ratios.