Therefore, in order to “target” the human breast “cancer stem cells”, one must design new chemopreventive and therapeutic strategies that will affect the expression of the (a) OCT4 (a gene needed to maintain the “stemness” of both the normal breast and breast “cancer” stem cells) and (b) connexin 43 gene (a gene required for allowing differentiation to occur in the normal human breast stem cells). Here, POU5F1 is linked to cancer.