In contrast, other reports show blockade of VEGFR3 promotes the inflammatory process in chronic arthritis [41] and cutaneous inflammation in keratin 14-VEGF-A transgenic mouse models [20], [41], and specific activation of lymphatic vessels by overexpression of VEGF-C or VEGF-D, or by injection of VEGF-C attenuates inflammatory edema in both chronic and acute cutaneous inflammation models [20], [42]. This evidence concerns the gene VEGFD and inflammatory response.