We also observed that down-regulation of FOXM1 inhibited proliferation, and demonstrated that TMPP suppressed FOXM1 expression, and that this FOXM1 repression reduced Cyclin B1 and Cdc25B mRNA expression, resulting in inhibition of the proliferation of AML-derived ALDHhi cells [2]. This evidence concerns the gene CCNB1 and acute myeloid leukemia.