Fig. 2B shows the data with methylation analyzed as a categorical variable. Concordant and discordant methylation between primary and metastatic tumors were respectively observed in 47 (23%) and 22 (11%) of 205 measurement pairs using a 15% cut-off value for methylation densities (Fig. 2B). A total of 183 (89%) measurement pairs showed concordant methylation status (methylation or lack of methylation). Discordant mutation was found in 2/11 (18%) tumor pairs with KRAS mutation and these two cases showed KRAS mutation in the primary tumors only (Fig. 2B). This evidence concerns the gene KRAS and metastatic neoplasm.